Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
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چکیده
منابع مشابه
Chemical proteomics: terra incognita for novel drug target profiling
The growing demand for new therapeutic strategies in the medical and pharmaceutic fields has resulted in a pressing need for novel druggable targets. Paradoxically, however, the targets of certain drugs that are already widely used in clinical practice have largely not been annotated. Because the pharmacologic effects of a drug can only be appreciated when its interactions with cellular compone...
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As alterations of the redox homeostasis lie at the root of many pathophysiological processes in human health, redox proteomics holds the promise to shed further light on fundamental biological processes. In this review, the mechanisms of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production are reviewed, mainly addressing those chemical phenomena which have already been a...
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Introduction In the past decade, DNA sequencing of multiple organisms has provided us with our first look at complete lists of protein products expressed from a whole genome. The field of proteomics is now challenged with the task of elucidating the cellular functions of these proteins in both normal and pathological processes (1–3). Several proteomic techniques, such as 2-dimensional gel-elect...
متن کاملExploiting polypharmacology for drug target deconvolution.
Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately, methods capable of exploiting the known polypharmacology of drugs for target deconvolution are lacking. Here, we present an ensemble approach using elastic net regularization combined with mRNA expression profiling and previously characterized data on a large set of ...
متن کاملChemical kinomics: a powerful strategy for target deconvolution.
Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase func...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2020
ISSN: 2213-2317
DOI: 10.1016/j.redox.2020.101491